Drug interactions
Dienogest / estradiol valerate + Nevirapine
Severity: Major
Dienogest / estradiol valerate and Nevirapine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine can lower sex hormone concentrations from this combined oral contraceptive, reducing contraceptive reliability and raising the risk of unintended pregnancy.
What this interaction means in plain words
Dienogest / estradiol valerate and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Nevirapine induces CYP3A4, increasing hepatic metabolism of dienogest and estradiol.
What to do
Use a different contraceptive method such as a copper IUD or DMPA, or add a barrier method. Avoid relying on this pill during and for weeks after nevirapine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Dienogest / estradiol valerate with Nevirapine?
MediHelp rates the interaction as major. Dienogest / estradiol valerate and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nevirapine can lower sex hormone concentrations from this combined oral contraceptive, reducing contraceptive reliability and raising the risk of unintended pregnancy.
How serious is the interaction between Dienogest / estradiol valerate and Nevirapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a different contraceptive method such as a copper IUD or DMPA, or add a barrier method. Avoid relying on this pill during and for weeks after nevirapine.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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