Drug interactions
Dienogest / estradiol valerate + Penicillin g
Severity: Minor
Dienogest / estradiol valerate and Penicillin g: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reduced estrogen recycling from altered gut flora has been proposed for antibiotics, but evidence of clinically significant loss of contraceptive efficacy is lacking for non-rifamycin antibiotics. The risk is low.
What this interaction means in plain words
Dienogest / estradiol valerate and Penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction of enterohepatic recirculation of estrogen through altered intestinal flora.
What to do
No additional contraception is routinely required; advise reporting breakthrough bleeding, vomiting or diarrhea, which may reduce efficacy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Penicillin g
- Amifampridine + Penicillin g Moderate
- Amiloride + Penicillin g Moderate
- Bcg vaccine live + Penicillin g Moderate
- Cholera vaccine + Penicillin g Moderate
- Colestipol + Penicillin g Moderate
- Deflazacort + Penicillin g Moderate
Frequently asked questions
Can I take Dienogest / estradiol valerate with Penicillin g?
MediHelp rates the interaction as minor. Dienogest / estradiol valerate and Penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reduced estrogen recycling from altered gut flora has been proposed for antibiotics, but evidence of clinically significant loss of contraceptive efficacy is lacking for non-rifamycin antibiotics. The risk is low.
How serious is the interaction between Dienogest / estradiol valerate and Penicillin g?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No additional contraception is routinely required; advise reporting breakthrough bleeding, vomiting or diarrhea, which may reduce efficacy.
What other medicines interact with Penicillin g?
MediHelp also lists interactions of Penicillin g with, for example, Amifampridine, Amiloride, Bcg vaccine live. The full list is on the Penicillin g page.
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