Drug interactions
Diethylpropion + Methamphetamine
Severity: Moderate
Diethylpropion and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sympathomimetic stimulants, and diethylpropion is an anorectic. Combined use produces additive increases in blood pressure and heart rate, with insomnia, agitation and arrhythmia risk. There is no therapeutic reason to combine them.
What this interaction means in plain words
Diethylpropion and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic sympathomimetic effects through catecholamine release.
What to do
Avoid combining stimulant anorectics. If unavoidable, monitor blood pressure, heart rate and cardiac symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Diethylpropion with Methamphetamine?
MediHelp rates the interaction as moderate. Diethylpropion and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are sympathomimetic stimulants, and diethylpropion is an anorectic. Combined use produces additive increases in blood pressure and heart rate, with insomnia, agitation and arrhythmia risk. There is no therapeutic reason to combine them.
How serious is the interaction between Diethylpropion and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining stimulant anorectics. If unavoidable, monitor blood pressure, heart rate and cardiac symptoms.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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