Drug interactions
Diethylpropion + Mirtazapine
Severity: Moderate
Diethylpropion and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a stimulant anorectic that may counteract mirtazapine sedation. Together they may cause agitation or blood pressure changes, and the net effect is hard to predict.
What this interaction means in plain words
Diethylpropion and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing stimulant and sedative effects with overlapping monoaminergic activity; not well characterized.
What to do
Monitor blood pressure, heart rate, sleep and mood. Reassess the combination if agitation or hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Diethylpropion with Mirtazapine?
MediHelp rates the interaction as moderate. Diethylpropion and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diethylpropion is a stimulant anorectic that may counteract mirtazapine sedation. Together they may cause agitation or blood pressure changes, and the net effect is hard to predict.
How serious is the interaction between Diethylpropion and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, sleep and mood. Reassess the combination if agitation or hypertension develops.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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