Drug interactions
Diethylpropion + Modafinil
Severity: Moderate
Diethylpropion and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are stimulants, and combined use may cause additive insomnia, anxiety, tachycardia and blood pressure elevation. Patients with cardiovascular disease are at higher risk.
What this interaction means in plain words
Diethylpropion and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS stimulant and sympathomimetic effects.
What to do
Monitor blood pressure, heart rate, sleep and mood. Avoid the combination in patients with uncontrolled hypertension or arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Diethylpropion with Modafinil?
MediHelp rates the interaction as moderate. Diethylpropion and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are stimulants, and combined use may cause additive insomnia, anxiety, tachycardia and blood pressure elevation. Patients with cardiovascular disease are at higher risk.
How serious is the interaction between Diethylpropion and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, sleep and mood. Avoid the combination in patients with uncontrolled hypertension or arrhythmia.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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