Drug interactions
Diethylpropion + Tramadol
Severity: Moderate
Diethylpropion and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic stimulant that may add to tramadol's seizure-lowering and serotonergic and noradrenergic effects. The stimulant may also mask opioid sedation, which can hide excessive dosing.
What this interaction means in plain words
Diethylpropion and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive lowering of seizure threshold and monoaminergic stimulation, with pharmacodynamic opposition of sedation.
What to do
Use the lowest effective tramadol dose and monitor for seizures, tachycardia, hypertension and agitation. Avoid in patients with a seizure history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Diethylpropion with Tramadol?
MediHelp rates the interaction as moderate. Diethylpropion and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diethylpropion is a sympathomimetic stimulant that may add to tramadol's seizure-lowering and serotonergic and noradrenergic effects. The stimulant may also mask opioid sedation, which can hide excessive dosing.
How serious is the interaction between Diethylpropion and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective tramadol dose and monitor for seizures, tachycardia, hypertension and agitation. Avoid in patients with a seizure history.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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