Drug interactions
Diethylpropion + Trazodone
Severity: Moderate
Diethylpropion and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic appetite suppressant and trazodone has adrenergic and serotonergic activity, so combined use may unpredictably alter blood pressure and heart rate. Serotonergic or agitation-related effects are also possible.
What this interaction means in plain words
Diethylpropion and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic overlap at adrenergic and serotonergic pathways; the mechanism is not firmly established.
What to do
Monitor blood pressure, pulse and symptoms of agitation or serotonin toxicity. Consider an alternative weight management strategy if cardiovascular effects arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Diethylpropion and Trazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Diethylpropion with Trazodone?
MediHelp rates the interaction as moderate. Diethylpropion and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diethylpropion is a sympathomimetic appetite suppressant and trazodone has adrenergic and serotonergic activity, so combined use may unpredictably alter blood pressure and heart rate. Serotonergic or agitation-related effects are also possible.
How serious is the interaction between Diethylpropion and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, pulse and symptoms of agitation or serotonin toxicity. Consider an alternative weight management strategy if cardiovascular effects arise.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
