Drug interactions
Diethylpropion + Trimipramine
Severity: Moderate
Diethylpropion and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic anorectic, and tricyclics alter responses to such drugs. The combination may cause hypertension, tachycardia and arrhythmia, or reduce the anorectic effect.
What this interaction means in plain words
Diethylpropion and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclic blockade of norepinephrine reuptake and neuronal uptake of indirect sympathomimetics alters adrenergic response.
What to do
Monitor blood pressure and heart rate closely, particularly at initiation. Consider an alternative weight-loss approach in patients with cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Diethylpropion with Trimipramine?
MediHelp rates the interaction as moderate. Diethylpropion and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diethylpropion is a sympathomimetic anorectic, and tricyclics alter responses to such drugs. The combination may cause hypertension, tachycardia and arrhythmia, or reduce the anorectic effect.
How serious is the interaction between Diethylpropion and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely, particularly at initiation. Consider an alternative weight-loss approach in patients with cardiovascular disease.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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