Drug interactions
Difelikefalin + Diphenoxylate-atropine
Severity: Minor
Difelikefalin and Diphenoxylate-atropine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin is a peripherally restricted kappa-opioid agonist, but somnolence and dizziness have been reported with it. Diphenoxylate can cause drowsiness at higher doses, so combined use may add to sedation. The clinical effect is generally modest.
What this interaction means in plain words
Difelikefalin and Diphenoxylate-atropine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Difelikefalin belongs to Dermatology; Diphenoxylate-atropine belongs to Gastrointestinal Tract.
Why it happens
Possible additive CNS depressant effects of two opioid-receptor-acting agents.
What to do
Counsel patients about drowsiness and advise against driving until the response is known. Keep diphenoxylate-atropine at the labeled dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Diphenoxylate-atropine?
MediHelp rates the interaction as minor. Difelikefalin and Diphenoxylate-atropine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Difelikefalin is a peripherally restricted kappa-opioid agonist, but somnolence and dizziness have been reported with it. Diphenoxylate can cause drowsiness at higher doses, so combined use may add to sedation. The clinical effect is generally modest.
How serious is the interaction between Difelikefalin and Diphenoxylate-atropine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and advise against driving until the response is known. Keep diphenoxylate-atropine at the labeled dose.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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