Drug interactions
Difelikefalin + Doxylamine
Severity: Moderate
Difelikefalin and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin is a kappa-opioid agonist that can cause dizziness and somnolence. Doxylamine may add to drowsiness and impaired alertness, particularly in dialysis patients.
What this interaction means in plain words
Difelikefalin and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difelikefalin belongs to Dermatology; Doxylamine belongs to Respiratory.
Why it happens
Additive CNS depression from kappa-opioid receptor agonism and central H1 blockade.
What to do
Monitor for somnolence, dizziness and falls. Prefer non-sedating antihistamines if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxylamine
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Doxylamine?
MediHelp rates the interaction as moderate. Difelikefalin and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin is a kappa-opioid agonist that can cause dizziness and somnolence. Doxylamine may add to drowsiness and impaired alertness, particularly in dialysis patients.
How serious is the interaction between Difelikefalin and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for somnolence, dizziness and falls. Prefer non-sedating antihistamines if one is needed.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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