Drug interactions
Difelikefalin + Imipramine
Severity: Moderate
Difelikefalin and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause somnolence and dizziness, and imipramine is also sedating, so combined use may increase drowsiness and the risk of falls. Patients receiving dialysis may be particularly susceptible.
What this interaction means in plain words
Difelikefalin and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difelikefalin belongs to Dermatology; Imipramine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; no pharmacokinetic mechanism is established.
What to do
Monitor for excessive sedation, dizziness and falls, and reduce the dose of either drug if symptoms arise. Counsel patients on caution with driving and other hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Imipramine?
MediHelp rates the interaction as moderate. Difelikefalin and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin can cause somnolence and dizziness, and imipramine is also sedating, so combined use may increase drowsiness and the risk of falls. Patients receiving dialysis may be particularly susceptible.
How serious is the interaction between Difelikefalin and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, dizziness and falls, and reduce the dose of either drug if symptoms arise. Counsel patients on caution with driving and other hazardous activities.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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