Drug interactions
Difelikefalin + Isoflurane
Severity: Minor
Difelikefalin and Isoflurane: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin, a peripherally restricted kappa opioid agonist, can cause somnolence and dizziness, which may add to anesthetic sedation. The effect is usually modest.
What this interaction means in plain words
Difelikefalin and Isoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Difelikefalin belongs to Dermatology; Isoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor postoperative sedation and recovery in dialysis patients receiving difelikefalin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoflurane
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Isoflurane?
MediHelp rates the interaction as minor. Difelikefalin and Isoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Difelikefalin, a peripherally restricted kappa opioid agonist, can cause somnolence and dizziness, which may add to anesthetic sedation. The effect is usually modest.
How serious is the interaction between Difelikefalin and Isoflurane?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor postoperative sedation and recovery in dialysis patients receiving difelikefalin.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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