Drug interactions
Difelikefalin + Lorazepam
Severity: Moderate
Difelikefalin and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin, a peripherally restricted kappa-opioid agonist, can cause somnolence and dizziness. Combined with lorazepam, these CNS effects may be additive, especially in dialysis patients.
What this interaction means in plain words
Difelikefalin and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difelikefalin belongs to Dermatology; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; difelikefalin acts on kappa receptors while lorazepam enhances GABA-A activity.
What to do
Monitor for excessive drowsiness, dizziness and falls, and reduce the lorazepam dose if sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Lorazepam?
MediHelp rates the interaction as moderate. Difelikefalin and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin, a peripherally restricted kappa-opioid agonist, can cause somnolence and dizziness. Combined with lorazepam, these CNS effects may be additive, especially in dialysis patients.
How serious is the interaction between Difelikefalin and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness, dizziness and falls, and reduce the lorazepam dose if sedation occurs.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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