Drug interactions
Difelikefalin + Oxybutynin
Severity: Moderate
Difelikefalin and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause somnolence and dizziness, and oxybutynin has sedating and cognitive effects. Together, central nervous system depression may be additive, with increased fall risk.
What this interaction means in plain words
Difelikefalin and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difelikefalin belongs to Dermatology; Oxybutynin belongs to Genitourinary.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for excessive drowsiness, dizziness and confusion, especially in older or dialysis patients, and counsel about driving and fall precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Oxybutynin?
MediHelp rates the interaction as moderate. Difelikefalin and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin can cause somnolence and dizziness, and oxybutynin has sedating and cognitive effects. Together, central nervous system depression may be additive, with increased fall risk.
How serious is the interaction between Difelikefalin and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness, dizziness and confusion, especially in older or dialysis patients, and counsel about driving and fall precautions.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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