Drug interactions
Difelikefalin + Scopolamine
Severity: Moderate
Difelikefalin and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin, a kappa opioid agonist, can cause dizziness, somnolence and confusion, and scopolamine may add to these CNS effects. The combination may increase sedation and fall risk.
What this interaction means in plain words
Difelikefalin and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difelikefalin belongs to Dermatology; Scopolamine belongs to Respiratory.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excess sedation, dizziness and confusion, particularly in dialysis patients and the elderly. Advise caution with driving and other activities requiring alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Scopolamine?
MediHelp rates the interaction as moderate. Difelikefalin and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin, a kappa opioid agonist, can cause dizziness, somnolence and confusion, and scopolamine may add to these CNS effects. The combination may increase sedation and fall risk.
How serious is the interaction between Difelikefalin and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, dizziness and confusion, particularly in dialysis patients and the elderly. Advise caution with driving and other activities requiring alertness.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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