Drug interactions
Diflunisal + Eltrombopag
Severity: Minor
Diflunisal and Eltrombopag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT1A1 in vitro, and diflunisal is cleared largely by glucuronidation, so exposure to diflunisal could rise. The clinical significance is uncertain.
What this interaction means in plain words
Diflunisal and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diflunisal belongs to Musculoskeletal; Eltrombopag belongs to Miscellaneous.
Why it happens
Possible inhibition of UGT-mediated glucuronidation of diflunisal by eltrombopag, not clinically established.
What to do
No routine dose change is needed; watch for increased NSAID adverse effects such as GI upset or renal changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Diflunisal with Eltrombopag?
MediHelp rates the interaction as minor. Diflunisal and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT1A1 in vitro, and diflunisal is cleared largely by glucuronidation, so exposure to diflunisal could rise. The clinical significance is uncertain.
How serious is the interaction between Diflunisal and Eltrombopag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for increased NSAID adverse effects such as GI upset or renal changes.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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