Drug interactions
Diflunisal + Emtricitabine
Severity: Moderate
Diflunisal and Emtricitabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Emtricitabine is eliminated by glomerular filtration and active tubular secretion, and NSAIDs can impair renal function and compete for tubular transport. Concurrent use, especially at high or repeated NSAID doses, may raise emtricitabine exposure and renal adverse effects.
What this interaction means in plain words
Diflunisal and Emtricitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Emtricitabine belongs to Anti Virals.
Why it happens
Reduced renal clearance through NSAID-related decreases in renal perfusion and competition for tubular secretion.
What to do
Prefer a non-NSAID analgesic in patients taking emtricitabine; if an NSAID is needed, monitor serum creatinine and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Emtricitabine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Emtricitabine Contraindicated
- Atidarsagene autotemcel + Emtricitabine Major
- Betibeglogene autotemcel + Emtricitabine Major
- Elivaldogene autotemcel + Emtricitabine Major
- Emtricitabine + Lamivudine Major
- Emtricitabine + Lovotibeglogene autotemcel Major
Frequently asked questions
Can I take Diflunisal with Emtricitabine?
MediHelp rates the interaction as moderate. Diflunisal and Emtricitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Emtricitabine is eliminated by glomerular filtration and active tubular secretion, and NSAIDs can impair renal function and compete for tubular transport. Concurrent use, especially at high or repeated NSAID doses, may raise emtricitabine exposure and renal adverse effects.
How serious is the interaction between Diflunisal and Emtricitabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic in patients taking emtricitabine; if an NSAID is needed, monitor serum creatinine and renal function.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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