Drug interactions
Diflunisal + Irbesartan
Severity: Moderate
Diflunisal and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal can weaken the antihypertensive effect of irbesartan and, together with an angiotensin receptor blocker, may impair renal function, especially in older or volume-depleted patients. Hyperkalemia can also occur.
What this interaction means in plain words
Diflunisal and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Irbesartan belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory renal prostaglandins reduces glomerular perfusion while ARB blocks efferent arteriolar tone, causing reduced filtration and potassium retention.
What to do
Monitor blood pressure, serum creatinine and potassium after starting the combination and ensure hydration. Avoid in patients with significant renal impairment or dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Diflunisal with Irbesartan?
MediHelp rates the interaction as moderate. Diflunisal and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diflunisal can weaken the antihypertensive effect of irbesartan and, together with an angiotensin receptor blocker, may impair renal function, especially in older or volume-depleted patients. Hyperkalemia can also occur.
How serious is the interaction between Diflunisal and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting the combination and ensure hydration. Avoid in patients with significant renal impairment or dehydration.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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