Drug interactions
Diflunisal + Prasugrel
Severity: Major
Diflunisal and Prasugrel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with a potent antiplatelet increases the risk of bleeding, particularly gastrointestinal. The risk is higher with chronic NSAID use.
What this interaction means in plain words
Diflunisal and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diflunisal belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.
Why it happens
Additive platelet inhibition (P2Y12 blockade plus COX-1 inhibition) and NSAID gastric mucosal injury.
What to do
Avoid chronic NSAID use with prasugrel where possible and use paracetamol. If necessary, add gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Prasugrel
Frequently asked questions
Can I take Diflunisal with Prasugrel?
MediHelp rates the interaction as major. Diflunisal and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an NSAID with a potent antiplatelet increases the risk of bleeding, particularly gastrointestinal. The risk is higher with chronic NSAID use.
How serious is the interaction between Diflunisal and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chronic NSAID use with prasugrel where possible and use paracetamol. If necessary, add gastroprotection and monitor for bleeding.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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