Drug interactions
Diflunisal + Probenecid
Severity: Moderate
Diflunisal and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are organic acids secreted by the renal tubules, and probenecid can reduce diflunisal clearance, raising diflunisal levels and toxicity risk. Diflunisal may also affect the uricosuric action of probenecid.
What this interaction means in plain words
Diflunisal and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits renal tubular anion transport and glucuronidation, reducing diflunisal elimination.
What to do
Monitor for NSAID adverse effects such as gastrointestinal and renal toxicity and consider reducing the diflunisal dose. Assess uric acid control in gout patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Diflunisal with Probenecid?
MediHelp rates the interaction as moderate. Diflunisal and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are organic acids secreted by the renal tubules, and probenecid can reduce diflunisal clearance, raising diflunisal levels and toxicity risk. Diflunisal may also affect the uricosuric action of probenecid.
How serious is the interaction between Diflunisal and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for NSAID adverse effects such as gastrointestinal and renal toxicity and consider reducing the diflunisal dose. Assess uric acid control in gout patients.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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