Drug interactions
Diflunisal + Sertraline
Severity: Moderate
Diflunisal and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs combined with NSAIDs considerably increase the risk of bleeding, especially upper gastrointestinal bleeding.
What this interaction means in plain words
Diflunisal and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Sertraline belongs to Central Nervous System.
Why it happens
SSRI-induced platelet serotonin depletion impairs aggregation, adding to NSAID antiplatelet effect and mucosal injury.
What to do
Monitor for gastrointestinal bleeding and consider a proton pump inhibitor in higher-risk patients. Keep the NSAID dose and duration minimal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Diflunisal with Sertraline?
MediHelp rates the interaction as moderate. Diflunisal and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs combined with NSAIDs considerably increase the risk of bleeding, especially upper gastrointestinal bleeding.
How serious is the interaction between Diflunisal and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal bleeding and consider a proton pump inhibitor in higher-risk patients. Keep the NSAID dose and duration minimal.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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