Drug interactions
Diflunisal + Sparsentan
Severity: Moderate
Diflunisal and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan, an endothelin and angiotensin receptor antagonist, lowers glomerular pressure, and NSAIDs reduce prostaglandin-mediated renal perfusion. Together they may worsen kidney function, particularly in volume-depleted or elderly patients, and can increase hyperkalemia risk.
What this interaction means in plain words
Diflunisal and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Sparsentan belongs to Genitourinary.
Why it happens
Combined reduction in efferent arteriolar tone from receptor blockade and loss of afferent vasodilation from NSAID prostaglandin inhibition.
What to do
Avoid regular NSAID use where possible and monitor serum creatinine and potassium. Ensure the patient is adequately hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Diflunisal with Sparsentan?
MediHelp rates the interaction as moderate. Diflunisal and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan, an endothelin and angiotensin receptor antagonist, lowers glomerular pressure, and NSAIDs reduce prostaglandin-mediated renal perfusion. Together they may worsen kidney function, particularly in volume-depleted or elderly patients, and can increase hyperkalemia risk.
How serious is the interaction between Diflunisal and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and monitor serum creatinine and potassium. Ensure the patient is adequately hydrated.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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