Drug interactions
Diflunisal + Sulindac
Severity: Moderate
Diflunisal and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two NSAIDs adds no meaningful therapeutic benefit but increases the risk of gastrointestinal ulceration and bleeding, renal impairment, and fluid retention. Platelet inhibition and mucosal injury are additive.
What this interaction means in plain words
Diflunisal and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Sulindac belongs to Musculoskeletal.
Why it happens
Additive inhibition of cyclooxygenase, reducing protective prostaglandins and platelet function.
What to do
Avoid concurrent use of two systemic NSAIDs and keep to a single agent at the lowest effective dose. If unavoidable, monitor for GI bleeding and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Diflunisal with Sulindac?
MediHelp rates the interaction as moderate. Diflunisal and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two NSAIDs adds no meaningful therapeutic benefit but increases the risk of gastrointestinal ulceration and bleeding, renal impairment, and fluid retention. Platelet inhibition and mucosal injury are additive.
How serious is the interaction between Diflunisal and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two systemic NSAIDs and keep to a single agent at the lowest effective dose. If unavoidable, monitor for GI bleeding and renal function.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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