Drug interactions
Diflunisal + Tolfenamic acid
Severity: Moderate
Diflunisal and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two NSAIDs together offers no added efficacy and raises the risk of gastrointestinal bleeding, renal injury and fluid retention. Antiplatelet effects are additive.
What this interaction means in plain words
Diflunisal and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition reducing gastroprotective prostaglandins and platelet aggregation.
What to do
Avoid combining NSAIDs and use a single agent at the lowest effective dose. If both are used, monitor for GI bleeding and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Diflunisal and Tolfenamic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Diflunisal with Tolfenamic acid?
MediHelp rates the interaction as moderate. Diflunisal and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using two NSAIDs together offers no added efficacy and raises the risk of gastrointestinal bleeding, renal injury and fluid retention. Antiplatelet effects are additive.
How serious is the interaction between Diflunisal and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining NSAIDs and use a single agent at the lowest effective dose. If both are used, monitor for GI bleeding and renal function.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
