Drug interactions
Digoxin + Dopexamine
Severity: Moderate
Digoxin and Dopexamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dopexamine, a beta-agonist, can lower serum potassium, which increases the risk of digoxin-induced arrhythmias. Both agents can also be arrhythmogenic through additive cardiac stimulation.
What this interaction means in plain words
Digoxin and Dopexamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-adrenergic stimulation shifts potassium into cells, and hypokalemia increases myocardial sensitivity to digoxin.
What to do
Monitor serum potassium and ECG during dopexamine therapy and replace potassium as needed. Watch for signs of digoxin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Dopexamine?
MediHelp rates the interaction as moderate. Digoxin and Dopexamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dopexamine, a beta-agonist, can lower serum potassium, which increases the risk of digoxin-induced arrhythmias. Both agents can also be arrhythmogenic through additive cardiac stimulation.
How serious is the interaction between Digoxin and Dopexamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG during dopexamine therapy and replace potassium as needed. Watch for signs of digoxin toxicity.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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