Drug interactions
Digoxin + Doxorubicin
Severity: Moderate
Digoxin and Doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytotoxic therapy including doxorubicin can impair gut absorption of digoxin tablets. This may reduce digoxin concentrations and therapeutic effect. Doxorubicin cardiotoxicity may also complicate heart failure management.
What this interaction means in plain words
Digoxin and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Doxorubicin belongs to Oncology.
Why it happens
Chemotherapy-related damage to the intestinal mucosa reduces absorption of oral digoxin.
What to do
Monitor digoxin levels and heart rate or heart failure symptoms during chemotherapy, and consider digoxin capsules or intravenous dosing if levels are low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Doxorubicin
Frequently asked questions
Can I take Digoxin with Doxorubicin?
MediHelp rates the interaction as moderate. Digoxin and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytotoxic therapy including doxorubicin can impair gut absorption of digoxin tablets. This may reduce digoxin concentrations and therapeutic effect. Doxorubicin cardiotoxicity may also complicate heart failure management.
How serious is the interaction between Digoxin and Doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin levels and heart rate or heart failure symptoms during chemotherapy, and consider digoxin capsules or intravenous dosing if levels are low.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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