Drug interactions
Digoxin + Enalapril
Severity: Minor
Digoxin and Enalapril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enalapril has little consistent effect on digoxin levels. ACE inhibitors may cause renal function changes or electrolyte shifts such as hyperkalemia that could influence digoxin handling or toxicity in some patients.
What this interaction means in plain words
Digoxin and Enalapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Enalapril belongs to Cardiovascular.
Why it happens
No consistent pharmacokinetic mechanism established; indirect effects through renal function and potassium changes may alter digoxin exposure.
What to do
Monitor digoxin levels, renal function and potassium when starting or changing enalapril, particularly in older patients or those with CKD.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Enalapril?
MediHelp rates the interaction as minor. Digoxin and Enalapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Enalapril has little consistent effect on digoxin levels. ACE inhibitors may cause renal function changes or electrolyte shifts such as hyperkalemia that could influence digoxin handling or toxicity in some patients.
How serious is the interaction between Digoxin and Enalapril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin levels, renal function and potassium when starting or changing enalapril, particularly in older patients or those with CKD.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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