Drug interactions
Digoxin + Encorafenib
Severity: Minor
Digoxin and Encorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib has been reported to inhibit transporters, including OATP1B1 and OATP1B3, and may increase exposure to some substrates. Digoxin is mainly a P-gp substrate with limited OATP dependence, so any rise in levels is uncertain and probably small.
What this interaction means in plain words
Digoxin and Encorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Encorafenib belongs to Oncology.
Why it happens
Possible transporter inhibition by encorafenib; the exact mechanism for digoxin is not well established.
What to do
Monitor digoxin concentration and for signs of toxicity when starting encorafenib. Adjust the digoxin dose if levels rise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Digoxin with Encorafenib?
MediHelp rates the interaction as minor. Digoxin and Encorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Encorafenib has been reported to inhibit transporters, including OATP1B1 and OATP1B3, and may increase exposure to some substrates. Digoxin is mainly a P-gp substrate with limited OATP dependence, so any rise in levels is uncertain and probably small.
How serious is the interaction between Digoxin and Encorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentration and for signs of toxicity when starting encorafenib. Adjust the digoxin dose if levels rise.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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