Drug interactions
Digoxin + Epinephrine racemic
Severity: Moderate
Digoxin and Epinephrine racemic: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine can increase ectopy and the risk of serious arrhythmias in patients taking digoxin. Beta-adrenergic effects may also lower serum potassium, increasing digoxin sensitivity.
What this interaction means in plain words
Digoxin and Epinephrine racemic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Adrenergic stimulation increases myocardial automaticity and drives potassium into cells, potentiating digoxin arrhythmogenicity.
What to do
Use the lowest effective epinephrine dose and monitor ECG and serum potassium. Correct hypokalemia and watch for signs of digoxin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Digoxin and Epinephrine racemic, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Epinephrine racemic?
MediHelp rates the interaction as moderate. Digoxin and Epinephrine racemic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine can increase ectopy and the risk of serious arrhythmias in patients taking digoxin. Beta-adrenergic effects may also lower serum potassium, increasing digoxin sensitivity.
How serious is the interaction between Digoxin and Epinephrine racemic?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective epinephrine dose and monitor ECG and serum potassium. Correct hypokalemia and watch for signs of digoxin toxicity.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
