Drug interactions
Digoxin + Exenatide
Severity: Minor
Digoxin and Exenatide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Exenatide delays gastric emptying, which might slightly reduce or delay digoxin absorption. Studies showed only a small effect on peak digoxin levels and no meaningful change in overall exposure.
What this interaction means in plain words
Digoxin and Exenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Exenatide belongs to Endocrine.
Why it happens
Slowed gastric emptying from exenatide delays oral absorption of digoxin.
What to do
No dose change is generally needed. Monitor clinical response and digoxin levels if heart rate control or toxicity is a concern.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Exenatide
- Chlorpropamide + Exenatide Major
- Asenapine + Exenatide Moderate
- Betamethasone + Exenatide Moderate
- Chlorothiazide + Exenatide Moderate
- Clozapine + Exenatide Moderate
- Cortisone + Exenatide Moderate
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Exenatide?
MediHelp rates the interaction as minor. Digoxin and Exenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Exenatide delays gastric emptying, which might slightly reduce or delay digoxin absorption. Studies showed only a small effect on peak digoxin levels and no meaningful change in overall exposure.
How serious is the interaction between Digoxin and Exenatide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor clinical response and digoxin levels if heart rate control or toxicity is a concern.
What other medicines interact with Exenatide?
MediHelp also lists interactions of Exenatide with, for example, Chlorpropamide, Asenapine, Betamethasone. The full list is on the Exenatide page.
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