Drug interactions
Digoxin + Fenoprofen
Severity: Moderate
Digoxin and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and glomerular filtration, which may raise digoxin concentrations in some patients. This can lead to digoxin toxicity, particularly in older people, those with renal impairment, or neonates.
What this interaction means in plain words
Digoxin and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Fenoprofen belongs to Musculoskeletal.
Why it happens
NSAID-related reduction in renal prostaglandins and clearance may decrease digoxin elimination.
What to do
Monitor serum digoxin concentration, renal function and potassium when starting or stopping the NSAID. Reduce the digoxin dose if levels rise or toxicity signs appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Fenoprofen?
MediHelp rates the interaction as moderate. Digoxin and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal function and glomerular filtration, which may raise digoxin concentrations in some patients. This can lead to digoxin toxicity, particularly in older people, those with renal impairment, or neonates.
How serious is the interaction between Digoxin and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentration, renal function and potassium when starting or stopping the NSAID. Reduce the digoxin dose if levels rise or toxicity signs appear.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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