Drug interactions
Digoxin + Fleroxacin
Severity: Minor
Digoxin and Fleroxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibacterials that alter gut flora can reduce bacterial inactivation of digoxin and raise its levels in some patients. Fleroxacin has limited supporting data, so the effect is uncertain.
What this interaction means in plain words
Digoxin and Fleroxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible suppression of intestinal bacteria that metabolize digoxin, increasing its bioavailability.
What to do
Monitor for signs of digoxin toxicity and check levels if symptoms arise. Adjust digoxin dose according to levels.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Digoxin and Fleroxacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Fleroxacin?
MediHelp rates the interaction as minor. Digoxin and Fleroxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibacterials that alter gut flora can reduce bacterial inactivation of digoxin and raise its levels in some patients. Fleroxacin has limited supporting data, so the effect is uncertain.
How serious is the interaction between Digoxin and Fleroxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of digoxin toxicity and check levels if symptoms arise. Adjust digoxin dose according to levels.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
