Drug interactions
Digoxin + Gepotidacin
Severity: Moderate
Digoxin and Gepotidacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepotidacin raises digoxin exposure, which may increase digoxin toxicity such as arrhythmias, nausea and visual disturbance.
What this interaction means in plain words
Digoxin and Gepotidacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Gepotidacin belongs to Anti Bacterial.
Why it happens
Inhibition of intestinal and renal P-glycoprotein-mediated digoxin transport.
What to do
Monitor digoxin serum concentrations and clinical signs of toxicity during gepotidacin therapy. Reduce the digoxin dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Gepotidacin?
MediHelp rates the interaction as moderate. Digoxin and Gepotidacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gepotidacin raises digoxin exposure, which may increase digoxin toxicity such as arrhythmias, nausea and visual disturbance.
How serious is the interaction between Digoxin and Gepotidacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin serum concentrations and clinical signs of toxicity during gepotidacin therapy. Reduce the digoxin dose if levels rise.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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