Drug interactions
Digoxin + Inamrinone
Severity: Minor
Digoxin and Inamrinone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs increase myocardial contractility through different pathways and may be used together in heart failure. Combined use may increase arrhythmia risk, though this is not well documented.
What this interaction means in plain words
Digoxin and Inamrinone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive positive inotropic effects via Na+/K+-ATPase inhibition and phosphodiesterase III inhibition.
What to do
Monitor ECG and electrolytes during combined use. Watch for arrhythmias.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Inamrinone?
MediHelp rates the interaction as minor. Digoxin and Inamrinone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs increase myocardial contractility through different pathways and may be used together in heart failure. Combined use may increase arrhythmia risk, though this is not well documented.
How serious is the interaction between Digoxin and Inamrinone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes during combined use. Watch for arrhythmias.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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