Drug interactions
Digoxin + Indinavir
Severity: Moderate
Digoxin and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir may inhibit P-glycoprotein and increase digoxin concentrations. This could cause digoxin toxicity, including arrhythmias.
What this interaction means in plain words
Digoxin and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits P-glycoprotein, increasing digoxin absorption and reducing renal and intestinal efflux.
What to do
Monitor serum digoxin levels and ECG when starting or stopping indinavir. Reduce the digoxin dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Indinavir?
MediHelp rates the interaction as moderate. Digoxin and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir may inhibit P-glycoprotein and increase digoxin concentrations. This could cause digoxin toxicity, including arrhythmias.
How serious is the interaction between Digoxin and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin levels and ECG when starting or stopping indinavir. Reduce the digoxin dose if levels rise.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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