Drug interactions
Digoxin + Ketorolac intranasal
Severity: Minor
Digoxin and Ketorolac intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and may raise serum potassium, with possible small increases in digoxin levels. With short-term intranasal use the effect is usually modest but may matter in renal impairment.
What this interaction means in plain words
Digoxin and Ketorolac intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
NSAIDs reduce renal prostaglandin-mediated blood flow, which may decrease digoxin clearance and raise potassium.
What to do
Monitor renal function and serum potassium, especially in older adults or those with kidney disease. Check digoxin levels if toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Ketorolac intranasal?
MediHelp rates the interaction as minor. Digoxin and Ketorolac intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can reduce renal function and may raise serum potassium, with possible small increases in digoxin levels. With short-term intranasal use the effect is usually modest but may matter in renal impairment.
How serious is the interaction between Digoxin and Ketorolac intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and serum potassium, especially in older adults or those with kidney disease. Check digoxin levels if toxicity is suspected.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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