Drug interactions
Digoxin + Ketorolac
Severity: Moderate
Digoxin and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may modestly raise digoxin concentrations and, by reducing renal function, increase the risk of digoxin toxicity. Evidence for ketorolac is limited.
What this interaction means in plain words
Digoxin and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Why it happens
NSAID-induced reduction in renal prostaglandins and glomerular filtration may decrease renal clearance of digoxin.
What to do
Monitor renal function, serum potassium and digoxin levels or toxicity signs during ketorolac use. Reduce the digoxin dose if concentrations rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Ketorolac?
MediHelp rates the interaction as moderate. Digoxin and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may modestly raise digoxin concentrations and, by reducing renal function, increase the risk of digoxin toxicity. Evidence for ketorolac is limited.
How serious is the interaction between Digoxin and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, serum potassium and digoxin levels or toxicity signs during ketorolac use. Reduce the digoxin dose if concentrations rise.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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