Drug interactions
Digoxin + Lansoprazole
Severity: Minor
Digoxin and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
PPIs may modestly increase digoxin absorption, with small rises in serum concentrations. This matters mainly in patients with a narrow margin, such as renal impairment or the elderly.
What this interaction means in plain words
Digoxin and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Raised gastric pH may reduce digoxin degradation and increase its absorption, and P-glycoprotein effects may contribute.
What to do
Monitor digoxin concentrations and signs of toxicity when starting or stopping lansoprazole in higher-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Lansoprazole?
MediHelp rates the interaction as minor. Digoxin and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. PPIs may modestly increase digoxin absorption, with small rises in serum concentrations. This matters mainly in patients with a narrow margin, such as renal impairment or the elderly.
How serious is the interaction between Digoxin and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentrations and signs of toxicity when starting or stopping lansoprazole in higher-risk patients.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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