Drug interactions
Digoxin + Levosalbutamol
Severity: Moderate
Digoxin and Levosalbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levosalbutamol can lower serum potassium, and hypokalemia increases the sensitivity of the heart to digoxin toxicity. Beta-agonists may also provoke tachyarrhythmias in patients with heart disease.
What this interaction means in plain words
Digoxin and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Levosalbutamol belongs to Respiratory.
Why it happens
Beta-2 agonist-induced intracellular potassium shift causes hypokalemia, which potentiates digoxin-related arrhythmias.
What to do
Monitor serum potassium, ECG and digoxin levels or toxicity symptoms, particularly with frequent or high-dose levosalbutamol. Correct hypokalemia promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Levosalbutamol?
MediHelp rates the interaction as moderate. Digoxin and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levosalbutamol can lower serum potassium, and hypokalemia increases the sensitivity of the heart to digoxin toxicity. Beta-agonists may also provoke tachyarrhythmias in patients with heart disease.
How serious is the interaction between Digoxin and Levosalbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, ECG and digoxin levels or toxicity symptoms, particularly with frequent or high-dose levosalbutamol. Correct hypokalemia promptly.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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