Drug interactions
Digoxin + Lumacaftor / ivacaftor
Severity: Moderate
Digoxin and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor can both induce and inhibit P-glycoprotein, and ivacaftor is a weak inhibitor, so digoxin exposure may change unpredictably. Either subtherapeutic or elevated digoxin levels could occur.
What this interaction means in plain words
Digoxin and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mixed induction and inhibition of intestinal and renal P-glycoprotein alters digoxin absorption and elimination.
What to do
Monitor serum digoxin concentrations and clinical response after starting or stopping lumacaftor/ivacaftor, adjusting the digoxin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Digoxin and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor can both induce and inhibit P-glycoprotein, and ivacaftor is a weak inhibitor, so digoxin exposure may change unpredictably. Either subtherapeutic or elevated digoxin levels could occur.
How serious is the interaction between Digoxin and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations and clinical response after starting or stopping lumacaftor/ivacaftor, adjusting the digoxin dose accordingly.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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