Drug interactions
Digoxin + Magnesium chloride
Severity: Minor
Digoxin and Magnesium chloride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Digoxin can modestly increase urinary magnesium loss, and hypomagnesemia increases the risk of digoxin toxicity. The effect is usually small, and magnesium supplements are generally appropriate.
What this interaction means in plain words
Digoxin and Magnesium chloride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Digoxin may increase renal magnesium excretion.
What to do
Monitor serum magnesium in patients on long-term digoxin, especially with diuretics. Correct hypomagnesemia if present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Magnesium chloride?
MediHelp rates the interaction as minor. Digoxin and Magnesium chloride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Digoxin can modestly increase urinary magnesium loss, and hypomagnesemia increases the risk of digoxin toxicity. The effect is usually small, and magnesium supplements are generally appropriate.
How serious is the interaction between Digoxin and Magnesium chloride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium in patients on long-term digoxin, especially with diuretics. Correct hypomagnesemia if present.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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