Drug interactions
Digoxin + Meclofenamate
Severity: Moderate
Digoxin and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can reduce renal prostaglandin synthesis and glomerular filtration, which may raise digoxin concentrations, especially in patients with heart failure or renal impairment. NSAIDs can also cause potassium retention and worsen renal function.
What this interaction means in plain words
Digoxin and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-induced reduction in renal blood flow and GFR decreases digoxin clearance and may cause hyperkalemia.
What to do
Monitor renal function, potassium and digoxin levels, and use the lowest effective NSAID dose for the shortest time. Consider alternative analgesics in heart failure or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Meclofenamate?
MediHelp rates the interaction as moderate. Digoxin and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meclofenamate can reduce renal prostaglandin synthesis and glomerular filtration, which may raise digoxin concentrations, especially in patients with heart failure or renal impairment. NSAIDs can also cause potassium retention and worsen renal function.
How serious is the interaction between Digoxin and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, potassium and digoxin levels, and use the lowest effective NSAID dose for the shortest time. Consider alternative analgesics in heart failure or renal impairment.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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