Drug interactions
Digoxin + Metaproterenol
Severity: Moderate
Digoxin and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaproterenol, a beta-agonist, can lower serum potassium and increase heart rate and ectopy, which may heighten susceptibility to digoxin-induced arrhythmias. The risk is greater with high or frequent dosing.
What this interaction means in plain words
Digoxin and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 mediated intracellular potassium shift causes hypokalemia, together with additive proarrhythmic effects.
What to do
Monitor serum potassium and ECG, correct hypokalemia, and use the lowest effective beta-agonist dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Metaproterenol?
MediHelp rates the interaction as moderate. Digoxin and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaproterenol, a beta-agonist, can lower serum potassium and increase heart rate and ectopy, which may heighten susceptibility to digoxin-induced arrhythmias. The risk is greater with high or frequent dosing.
How serious is the interaction between Digoxin and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG, correct hypokalemia, and use the lowest effective beta-agonist dose.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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