Drug interactions
Digoxin + Metformin-sitagliptin
Severity: Moderate
Digoxin and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Digoxin and metformin may compete for renal secretion and slightly raise each other's levels. Clinically significant changes are uncommon but digoxin has a narrow therapeutic index.
What this interaction means in plain words
Digoxin and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Competition for renal tubular secretion by cationic transporters; digoxin is also a P-gp substrate.
What to do
Monitor serum digoxin concentrations and signs of toxicity when starting or changing metformin. Check renal function periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Digoxin and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Digoxin and metformin may compete for renal secretion and slightly raise each other's levels. Clinically significant changes are uncommon but digoxin has a narrow therapeutic index.
How serious is the interaction between Digoxin and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations and signs of toxicity when starting or changing metformin. Check renal function periodically.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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