Drug interactions
Digoxin + Metformin
Severity: Minor
Digoxin and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are eliminated partly by renal tubular secretion, and digoxin may modestly alter metformin exposure. The clinical effect is usually small, but renal impairment can magnify it and affect both drugs.
What this interaction means in plain words
Digoxin and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
Possible competition for renal tubular transporters, including organic cation transporters.
What to do
No routine dose adjustment is needed; monitor renal function and digoxin levels, especially in older patients or those with reduced kidney function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Metformin
Frequently asked questions
Can I take Digoxin with Metformin?
MediHelp rates the interaction as minor. Digoxin and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are eliminated partly by renal tubular secretion, and digoxin may modestly alter metformin exposure. The clinical effect is usually small, but renal impairment can magnify it and affect both drugs.
How serious is the interaction between Digoxin and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed; monitor renal function and digoxin levels, especially in older patients or those with reduced kidney function.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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