Drug interactions
Digoxin + Methyclothiazide
Severity: Moderate
Digoxin and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics such as methyclothiazide cause potassium and magnesium loss, and the resulting hypokalemia sensitizes the myocardium to digoxin and can precipitate arrhythmias. This is a clinically well-recognized interaction.
What this interaction means in plain words
Digoxin and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Diuretic-induced hypokalemia and hypomagnesemia enhance digoxin binding to Na+/K+-ATPase and its toxicity.
What to do
Monitor serum potassium and magnesium regularly and replace deficits, targeting normal potassium. Monitor digoxin levels and for toxicity symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Methyclothiazide?
MediHelp rates the interaction as moderate. Digoxin and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics such as methyclothiazide cause potassium and magnesium loss, and the resulting hypokalemia sensitizes the myocardium to digoxin and can precipitate arrhythmias. This is a clinically well-recognized interaction.
How serious is the interaction between Digoxin and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and replace deficits, targeting normal potassium. Monitor digoxin levels and for toxicity symptoms.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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