Drug interactions
Digoxin + Metoclopramide intranasal
Severity: Minor
Digoxin and Metoclopramide intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide speeds gastric emptying and intestinal transit, which may reduce absorption of slowly dissolving digoxin tablets and lower serum levels. The effect is most relevant for oral digoxin formulations with poor dissolution.
What this interaction means in plain words
Digoxin and Metoclopramide intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Increased GI motility shortens contact time and reduces digoxin absorption.
What to do
Monitor digoxin concentrations and clinical response, and adjust the dose if levels fall. Using a liquid or capsule digoxin formulation may lessen the effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Metoclopramide intranasal?
MediHelp rates the interaction as minor. Digoxin and Metoclopramide intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metoclopramide speeds gastric emptying and intestinal transit, which may reduce absorption of slowly dissolving digoxin tablets and lower serum levels. The effect is most relevant for oral digoxin formulations with poor dissolution.
How serious is the interaction between Digoxin and Metoclopramide intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentrations and clinical response, and adjust the dose if levels fall. Using a liquid or capsule digoxin formulation may lessen the effect.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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