Drug interactions
Digoxin + Nefazodone
Severity: Moderate
Digoxin and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone has been reported to raise digoxin concentrations, likely through inhibition of P-glycoprotein efflux. Elevated digoxin may lead to toxicity including arrhythmias and gastrointestinal or visual symptoms.
What this interaction means in plain words
Digoxin and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-glycoprotein reduces digoxin elimination and increases its exposure.
What to do
Monitor digoxin concentrations and ECG when starting or stopping nefazodone, and reduce the digoxin dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Nefazodone?
MediHelp rates the interaction as moderate. Digoxin and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone has been reported to raise digoxin concentrations, likely through inhibition of P-glycoprotein efflux. Elevated digoxin may lead to toxicity including arrhythmias and gastrointestinal or visual symptoms.
How serious is the interaction between Digoxin and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentrations and ECG when starting or stopping nefazodone, and reduce the digoxin dose if levels rise.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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