Drug interactions
Digoxin + Neomycin po
Severity: Moderate
Digoxin and Neomycin po: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin can reduce digoxin absorption, lowering serum levels and effect, and the effect may persist for days after stopping. Conversely, suppression of gut bacteria that inactivate digoxin can raise levels in some patients, so the net effect is variable.
What this interaction means in plain words
Digoxin and Neomycin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Neomycin causes malabsorption of digoxin and eliminates Eubacterium lentum, which metabolizes digoxin in the gut.
What to do
Monitor digoxin concentrations and clinical response during and after neomycin therapy. Adjust the dose as needed, or separate dosing and consider a liquid or capsule formulation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Neomycin po?
MediHelp rates the interaction as moderate. Digoxin and Neomycin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral neomycin can reduce digoxin absorption, lowering serum levels and effect, and the effect may persist for days after stopping. Conversely, suppression of gut bacteria that inactivate digoxin can raise levels in some patients, so the net effect is variable.
How serious is the interaction between Digoxin and Neomycin po?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentrations and clinical response during and after neomycin therapy. Adjust the dose as needed, or separate dosing and consider a liquid or capsule formulation.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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