Drug interactions
Digoxin + Norepinephrine
Severity: Moderate
Digoxin and Norepinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norepinephrine can provoke arrhythmias, and in patients on digoxin the risk of ventricular ectopy and serious arrhythmias is increased. Catecholamine-induced potassium shifts may further contribute.
What this interaction means in plain words
Digoxin and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive proarrhythmic effects through increased myocardial automaticity and possible catecholamine-related hypokalemia.
What to do
Monitor ECG continuously and keep serum potassium and magnesium in the normal range during norepinephrine infusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Norepinephrine?
MediHelp rates the interaction as moderate. Digoxin and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Norepinephrine can provoke arrhythmias, and in patients on digoxin the risk of ventricular ectopy and serious arrhythmias is increased. Catecholamine-induced potassium shifts may further contribute.
How serious is the interaction between Digoxin and Norepinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG continuously and keep serum potassium and magnesium in the normal range during norepinephrine infusion.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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